Chemoprevention of Human Prostate Cancer by Green Tea Catechins: Two Years Later. A Follow-up Update

Prostate cancer (CaP) progresses slowly and clinical is usually diagnosed in very elderly men. Delaying disease onset by a few years would reduce incidence, which makes it an ideal target for chemoprevention strategies. We and others showed that both Green Tea Catechin (GTC) and EGCG possess anti-tumour activity in vitro, as well as in vivo in the TRAMP mouse model [1,2]. We suggested that administration of GTCs might be beneficial in the early stages of cell transformation but not later, when cancer had already developed.