Fraud Blocker

A 13-week dietary toxicity and toxicokinetic study with l-theanine in rats

A 13-week dietary toxicity and toxicokinetic study with l-theanine in rats

Author: Borzelleca JF, and Peters D, and Hall W

This study was conducted to evaluate the safety of l-theanine (Suntheanine®) when administered as a dietary admixture to male and female Crl:CD® (SD)GS BR rats at concentrations providing doses of 0, 1500, 3000 or 4000 mg/kg bw/day for 13 weeks. The study design was consistent with OECD Guideline 408 and USFDA Redbook II (1993) and GLP. There were no consistent, statistically significant treatment-related adverse effects on behavior, morbidity, mortality, body weight, food consumption and efficiency, clinical chemistry, hematology, or urinalysis. There were no consistent treatment-related adverse effects in gross pathology, organ weights or ratios or histopathology. The increased incidence of renal tubular cell adenomas in high-dose females only were not consistent with the characteristics of a renal carcinogen (due to early onset and low number of animals affected) but were more consistent with a genetic predisposition than with direct organ toxicity. The no-observed-adverse-effect-level (NOAEL) was 4000 mg/kg bw/day, the highest dose tested.

 

Get the whole article here

Shipping Icon Free shipping on subscriptions + orders over $49 (US only)

{property.value} {property.value} {property.value} Include jar: {property.value}

Delivery every {property.value}

{property.value}

+
You definitely need tools!
Perfect coldbrew everytime
The ideal way to store your matcha
The ideal way to store your matcha